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남구 명예기자 윤두선
5뤌12일(금)~14일(일), 부처님 오신 날 행사가 태화강둔치에서 열려 다녀왔습니다.
12일 개회식에는 울산 근교의 사찰과 해외 불교국에서 온 불자와 스님들이 대거 참여를 해 부처님 오신 날을 봉축했습니다.
부처님 오신 날을 봉축하기 위해 태화교와 태화강변으로 약10만개의 오색찬란한 연등이 켜져 도심을 수놓았습니다.
*연등의 의미 – 석가모니부처님의 탄신일(음력 4월 8일)을 축하하고, 연꽃모양 등燈에 불을 밝혀 무지와 번뇌로 가득찬 속세를 부처님의 자비로 밝혀 주는 것
봉축 법요식
-상단불공 – 10시
-법요식 – 11시 20분
-정근기도 – 14시
-점등식 및 회향 법회 – 19시
필자는 점등식 및 회향 법회에 참여를 했습니다.
밤이 되자 연등이 강물속에도 비춰져 마치 연꽃이 핀 것 처럼 연출되었습니다.
물속의 연등을 들여다보고 있을 때 사람들의 환호성이 들려 고개를 돌려보니 연등행렬이 줄지어 들어오고 있었습니다.
필자도 연등행렬속으로 자리를 옮겨 축제를 즐겼습니다.
연등행렬은 여러 사찰에서 준비한 다양한 모양의 연등으로 로봇, 공작새, 봉황, 연꽃, 코끼리, 탑, 부처님상……
연등을 실은 자동차가 들어올때 마다 불자들은 합장을 올리고, 연거푸 사진을 찍었습니다.
모든 연등이 의미가 있었지만 연등중에서 가장 인기가 좋았던 연등은 단연코 공작새였습니다.
보고 있으면 금방이라도 날아갈 것처럼 느껴져 눈을 뗄 수가 없었습니다.
화려한 공작새의 날개짓은 연등행사를 압도했습니다.
또한 불교국가에서 온 외국인들이 자국의 전통의상을 입고 연등행사에 참여해 눈길을 끌기도 했습니다.
사람들은 연등을 찍어 SNS에 올리기 바빴고, 필자도 사진을 수십장 찍었습니다.
그밖에도 3일에 걸쳐 봉축 제등 행렬, 연등 탑돌이, 축하공연 및 불꽃놀이, 부처님 이운행렬, 부처님 찬탄 게송 대회, 발우공양 체험 등 다양한 프로그램이 있었습니다.
체험부스에서는 불교용품, 천연염색 등 다양한 체험을 할 수 있었으나 필자가 도착했을 때는 문을 닫은 상태여서 아쉽게도 체험을 하지 못했습니다.
점등식 및 개회식이 끝나고 불꽃놀이가 시작되었습니다.
불꽃놀이는 제법 긴 시간 동안 이어졌고, 불꽃이 하늘을 향해 쏘아 오르자 구경꾼들의 함성도 덩달아 울려퍼졌습니다.
이번이 마지막 불꽃이겠거니 하고 숨죽여 보고 있으면 거짓말처럼 또 불꽃이 솟아 오르고…..그렇게 불꽃은 계속 이어졌습니다.
태화강둔치에 있던 구경꾼들은 말할 것도 없고, 지나가던 차들도, 주위의 아파트에서도 불꽃을 사진으로 찍어 지인분들한테 보내느라 정신이 없었습니다.
불꽃놀이는 우뢰와 같은 폭음을 내 시선을 집중시켜 놓고 하늘에다 불꽃을 만들어 온 세상을 밝히고는 금방 사라져 버리는 것이기에 지켜보거나 사진으로 남기지 않으면 다시는
그 장면을 볼 수 없다는 것 때문에 매력적이지 않나 생각합니다.
불꽃놀이 행사가 끝나고 주위를 둘러보았습니다.
그 넓은 행사장에는 쓰레기가 하나도 없었습니다.
해마다 태화강둔치에서 불교 행사를 하지만 다른 행사와는 사뭇 다르다는 걸 느낍니다.
행사 시작과 행사 종료때까지 쓰레기는 찾아볼 수 없었고, 버리는 사람도 없지만 주최측에서 그만큼 철저하게 관리를 했다는 말이기도 합니다.
쓰레기 없는 ‘부처님 오신 날’ 행사를 치른 불교연합회에 진심으로 감사를 드립니다.
부처님의 자비가 온누리에 함께 하기를…..합장
1 Comments
Due To This Fact, there could be rising evidence that myostatin inhibitors can enhance muscle function within the mdx
mouse via an increase in muscle mass and complete
drive but don’t constantly enhance the underlying weak spot of dystrophic muscle.
It has been instructed that the diploma of muscle disease at the time of treatment may affect consequence [43].
Human muscular dystrophy issues display paradoxical muscle wasting and selective hypertrophy of skeletal muscular tissues, resulting in imbalance, contractures and postural instabilities [37▪▪].
Dysferlin null mice, a mannequin of dysferlin-deficiency muscular dystrophy [48], expressing the myostatin inhibitor follistatin, demonstrated a transient increase
in muscle mass followed by decreased muscle mass and function and elevated muscle fibrosis [Lee et al.
A characterization of myostatin expression in main tumors is warranted in mild of these initial findings. Cordycepin, also called 3′-deoxyadenosine, is a key energetic compound found in Cordyceps militaris9. Analysis has shown that cordycepin displays antioxidant10, anti-inflammatory11, and neuroprotective effects12. Moreover, earlier analysis has indicated that cordycepin can enhance contractility of isolated skeletal muscles and delay the onset of train fatigue in isolated skeletal muscles14. Forced treadmill exercise is a typical modeling methodology to induce fatigue by forcing experimental animals to perform extreme train, in addition, forced treadmill train is extensively used in pharmacology, fatigue dietary supplements, and sports-related fields. Augmentation of protein or vitality intake with out concurrently addressing inflammation and oxidative stress via the administration of anti-inflammatory brokers or antioxidants may not lead to favorable outcomes.
Leptin signaling, through the hypothalamic melanocortin receptors, acts as a possible mediator of inflammation-induced cachexia and anorexia in CKD. Kidneys clear the circulating leptin, therefore, its serum focus is elevated in uremia and CKD [143].
Leptin is taken into the mind by the blood-brain barrier (BBB) and
binds to the leptin receptor, suppressing meals consumption by inhibiting the arcuate nucleus of the hypothalamus.
Leptin controls cachexia by way of modifying energy expenditure and food consumption through the hypothalamic melanocortin system [21].
In CKD sufferers, the decreased renal function leads to an elevation in leptin ranges, most likely due
to diminished renal clearance, thus, elevated levels of leptin are associated to poor dietary statuses, such
as hypercatabolism and low serum albumin [9, 144].
In the hypothalamic arcuate nucleus neurons, Proopiomelanocortin (POMC, a pro-peptide precursor)
is produced that impedes vitality storage and meals consumption by releasing α–melanocyte-stimulating hormone (α-MSH) [145].
Α-MSH prohibits meals consumption by binding to melanocortin receptors-3 and − 4 (MC3-R and MC4-R), primarily through MC4-R [134].
Additional development of domagrozumab was finally terminated in 2018 due to
the lack of constructive results from these research [49].
Both of those groups skilled important increases in muscle thickness
and Fortetropin decreased markers of protein breakdown. ACVRIIB is a widely reported signaling receptor
for several members of the TGF-β superfamily. ACVRIIB is concerned in the unfavorable regulation of muscle mass and is extensively distributed in SM, adipose tissues, and different
organs.
Satisfactory development, and restore of skeletal muscle
depending on the kind of cells. SCs are a subpopulation of skeletal muscle progenitors and are positioned beneath the
basal lamina of myocytes. In healthy conditions, these cells stay inactive until encountering an activating
stimulus such as injury or train which outcomes in the initiation of the cell cycle and differentiation to myoblasts,
promoting the regeneration or progress of myocytes [93].
It has been demonstrated that people with CKD possess
a smaller amount of SCs of their skeletal muscle and the remaining SCs have irregular function, lowering the regenerative capacity of their skeletal muscle [94].
All of those mentioned alterations contribute to the method of muscle wasting in CKD patients.
This is accomplished by focusing on androgen receptors and
blocking myostatin, a protein that regulates muscle improvement.
As a end result, it’s a very promising supplement for bodybuilders seeking to bulk up.
YK11 is a strong and unique SARM that not solely capabilities as a muscle builder but in addition as
a myostatin inhibitor, encouraging muscle progress by
lowering its regulation. YK11 has no negative results on the liver, in contrast to other forms
of testosterone, since it’s not metabolized there.
Ecdysterone (20-Beta-Hydroxyecdysterone) is a plant sterol that has additionally been linked to some bold claims together
with promotion of protein synthesis, maintenance of anabolic state, and enhancement of
lean muscle mass, whereas subsequently reducing adipose tissue.
Please understand that the FDA hasn’t approved these
dietary supplements to prevent age-related muscle losing or are guaranteed
to end in muscle growth. Nonetheless, we needed to take a more in-depth take a look at these
compounds to see how they may work to support myostatin inhibition. Like any intervention within the
body’s natural processes, you want to cautiously approach these things.
While pure myostatin inhibitors are generally thought-about safe when used appropriately, consulting with a healthcare provider is
all the time a good practice, especially when altering something as fundamental as muscle development
regulation. Myocytes of the heart and myoblasts (precursors of skeletal muscle cells) comprise the gene — MSTN — that regulates myostatin levels.
As such, relative myostatin mRNA expression is a standard biomarker in epicatechin research.
Myostatin (MSTN), which is referred to as a myokine,
belongs to the reworking progress factor β (TGF-β) superfamily
and, as mentioned above, acts as a unfavorable regulator of muscle progress.
Serum MSTN has been reported to be a serious risk factor of pre-sarcopenia and sarcopenia [14,15], whereas MSTN knockout (MSTN−/−) mice exhibited greater myofiber dimension, muscle weight, and
grip energy than wild-type controls [16]. Fibromodulin (FMOD) is an extracellular matrix (ECM) gene expressed abundantly
in muscle and connective tissues corresponding to cartilage, pores and
skin, and tendons [17] and an MSTN regulator that controls muscle cell formation in the course of
the myogenic program [18].
Follistatin, in extra, raises the risk of several malignancies, including cutaneous,
esophageal, stomach, and prostate most cancers. Nevertheless, excessive
ranges of Follistatin have been found to have a
preventive impression against breast most cancers, while further
examine is needed.It is essential to know that, like other anabolic steroids,
YK11 can cause various antagonistic effects ranging from minor to extreme.
Elevated hair development, pimples, modifications in libido, sleeplessness, nervousness, irritability, nausea, and complications
are all common unwanted effects. Excessive blood strain, liver
harm, renal damage, and coronary heart damage are all potential opposed results.Given the hazards, it’s instructed that only these with previous expertise with anabolic steroid use
[hubpages.com] think about utilising YK11.
Those considering YK11 supplements should pay attention to the
hazards and proceed with caution.
Moreover, PPIs between FMOD and MSTN and its
receptor (Activin receptor type-IIB, ACVRIIB) showed that FMOD effectively reduced the interplay between MSTN and
ACVRIIB (Lee et al., 2016). None of the supplements discussed in this article, including epicatechin, are FDA-approved for growing muscle dimension, maximizing
energy positive aspects, or preventing muscle atrophy.
Dietary dietary supplements should be considered adjunct instruments and a part of a extra holistic approach
to wellness alongside food plan, train, and stress
reduction. Omega-3 fatty acids, particularly these
found in fish oil, contribute to muscle health by decreasing irritation and possibly influencing the genetic signaling pathways concerned in muscle progress, together with
these regulating myostatin. Omega-3s are important for overall well being and have been shown to assist
muscle recovery and performance.
MSTN inhibition is taken into account to be a potentially effective technique
of addressing the problem of muscle loss. Computational methods are extensively used to discover novel inhibitors
in a fast and cost-effective manner, usually by way of peptide design and compound
screening. Normally, peptides are generated based on the 3D structures
of protein complexes (Baig et al., 2018). Peptide fragments are often created from the interacting residues of protein-protein interactions (PPIs), that are central considerations in rational
drug design (Baig et al., 2016). Computational
screening of large compound collections against the binding sites of goal proteins often leads to the rapid identification of potential ligands.
Virtual screening (VS.) is usually carried out utilizing
structure- and ligand-based approaches (Baig et al., 2016).
Recently, Mak et al. examined the differential impacts of 25(OH)D3 versus 1,25(OH)2D3 repletion in a mice mannequin of CKD.
Intraperitoneal administration of 25(OH)D3 or 1,25(OH)2D3 (for 6 weeks)
could elevate serum ranges of 1,25(OH)2D3 or 25(OH)D3. The 25(OH)D3 may enhance lean and
fat mass, weight achieve, urge for food, and muscle operate, and reduce an elevated resting metabolic rate in comparability
to the 1,25(OH)2D3 repletion. In Addition To, 25(OH)D3 decreased
adipose tissue browning and enhanced power homeostasis
in skeletal muscle and adipose tissue, whereas 1,25(OH)2D3 did show the identical results.
Normalization of the molecular pathways linked with muscle fibrosis dysregulated gene expression of regulatory signaling
in muscle mass, and muscle expression profile related to skeletal
muscle losing was additionally detected after 25(OH)D3 repletion. Taken all collectively, they concluded that the
repletion of 25(OH)D3 was deemed to be advantageous over 1,
25(OH)2D3 through lowering muscle losing and adipose
tissue browning in CKD mice [171].
Which antidepressant is greatest for you is dependent upon several components, similar to your symptoms and some other health circumstances you could have.
All SNRIs work in much the identical means and customarily
could cause the same sorts of unwanted facet effects.
Aspect results that do occur are usually mild and go away after the first few weeks of treatment.
If you presumably can’t deal with the side effects of one SNRI, you may have fewer unwanted aspect effects with
a different one, as every SNRI has a unique chemical make-up.
An optimum medical trial design would need to incorporate a major number of subjects, completely different age
and sex cohorts, use placebo teams and be blinded.
Rigorous measures of SkM mass, power and endurance
would need to be included corresponding to using Dual-energy X-ray absorptiometry
(DEXA) scans, dynamometry and cycle ergometry.
The pursuit of such trials will hopefully make
clear the prospects for an emerging pure and protected compound for use in the remedy of sarcopenia.
Clients have mixed opinions about the protein content of the nutritional supplement.
Some say it’s a healthy food for warriors and works
nicely with a great diet and train. Others point out it must be taken 5 times a day, is pricey,
and has less protein than 2 eggs. Hippocampal tissue
was collected from the mice and homogenates had been quickly prepared
in an ice bath.
This research was funded by a research grant from MuscleTech Research & Improvement, Inc., (Mississauga, ON)
to Baylor College. Researchers within the ESNL
independently collected, analyzed and interpreted the results from this study
and haven’t any financial pursuits in the outcomes of this examine.
Presentation of results in this examine doesn’t constitute endorsement by Baylor University or its authors of
the supplements investigated.
Moreover, the stimulation of Sirtuin 1 (SIRT1) and
NRF2 signaling systems has been documented to mitigate mitochondrial injury
and improve kidney exercise, proteinuria, histological alterations, and inflammation in aged mice.
Additional analysis is required to research the potential impression of resveratrol on protein-energy wasting amongst people with CKD.
This study supplies the first direct evidence of metabolically useful results of Urolithin A in major human skeletal muscle cells.
After a familiarization session on the screening day, unilateral isometric knee-extensor torque was measured
utilizing the BIODEX (System 3, Biodex Medical Methods, Shirley, NY, USA) on days 1, 14, 28,
and 42. The dynamometer was set to 60° from the resting (90°) position, and participants
carried out four maximal voluntary isometric leg extensions, lasting 5
seconds for 4 repetitions, 2 min aside. The common of the best
recorded 3 trials was used for maximal strength per go to.
NS and ZB were the principal investigators and had primary responsibility for the
final content. Complete serum antioxidant capability expressed as Trolox equivalents (TE) for every group and time point.denotes a big difference for
the principle impact of time. (A) Relative peak anaerobic power, (B) relative anaerobic capability, and (C) fatigue index results for every group and time level.denotes a major difference for the main impact
of time.
Cocoa extracts that contain epicatechin may help in promoting better blood flow and in enhancing the cells sensitivity
to insulin. In vitro and in vivo experiments were
done on Leydig cells (cells liable for producing testosterone).
IGF-1 LR3 works by making muscular tissues extra sensitive to insulin which
leads to the building of muscle tissues. What separates follistatin 344
from the the rest of the proteins is that relatively less intake can bring long-lasting effects
on the body. Although follistatin 344 is a recombinant derivative of naturally occurring
follistatin, the dearth of human-based scientific trials nonetheless makes it an illegal substance
for people to eat.
Prospects discover that the dietary complement helps them preserve muscle power
and recovery. However, some customers have reported issues with the dosage being half what advertised, and the nutrition label not matching the product pictures.
Customers are satisfied with the nutritional
supplement’s effectiveness and quality components.
These preliminary study results are provocative and warrant further rigorous examination.
The mechanisms of MSTN-induced SM loss are mediated by lowered protein synthesis and/or enhanced protein catabolism (Elliott et al., 2012).
MSTN decreases protein synthesis by inhibiting the Akt/mTOR signaling pathway
and induces muscle atrophy by selling the transcriptions of atrophy-related genes (atrogenes).
MSTN signaling pathways could be divided into Smad and non-Smad mediated pathways
(Figure 1). The extracellular matrix (ECM) is
a posh construction comprised of various structural molecules that provide
mechanical support to cells and keep biochemical signaling (Zhang et al.,
2021). Myostatin, also referred to as progress differentiation issue 8 (GDF-8), is a protein that inhibits
muscle growth.
Moreover, Smad2/3 phosphorylation by myostatin triggers
atrophy in grownup muscle fibers partially by way of upregulation of an ubiquitin ligase atrogin1 [36].
In addition, through a Smad2-dependent elevation of nuclear
issue of activated T cells 1, myostatin was just lately described to instantly speed up the formation of osteoclasts from bone marrow-derived macrophages,
increasing bone resorption [7]. For one, epicatechin seems to
extend aerobic and anaerobic fitness by bolstering mitochondrial biogenesis and nitric oxide production [8].
Apart From that, we noticed the elevated phosphorylated p70S6K
at post-immobilization in FOR-SUPP (Fig 7D), which shouldn’t be disregarded.
ACE-083, developed by Acceleron/Merck, is a fusion protein consisting
of a human IgG2 Fc domain linked with a modified human FST.
ACE-083 is designed for intra-muscular injection and causes localized MSTN inhibition.
Hence, exploiting phytoestrogens can exert a major anti-inflammatory effect, which may be beneficial in cachectic CKD sufferers.
A excessive dietary fiber content material and ω-3 fatty acids of fish oil particularly eicosapentaenoic acid can reduce
pro-inflammatory cytokines (i.e. IL-6 and CRP) levels in non-renal sufferers [7, 16].
Nevertheless, it was reported that fish consumption in dialysis sufferers might decrease the mortality rate (approximately 50%) through the statement period [167].
Nevertheless, in distinction to myostatin that’s primarily expressed in skeletal muscle, activins and BMPs are expressed in all kinds
of tissues to manage the growth and differentiation of quite a few cell varieties, and due
to this fact, their inhibition may end in serious adverse results.
The potential unwanted facet effects of myostatin inhibitors will be discussed in the subsequent section. The
final supplement investigated was sulfo-polysaccharide,
which is marketed to bind to myostatin and inhibit
its exercise in skeletal muscle. Of the three dietary
supplements examined in our study, sulfo-polysaccharide supplementation has one of the
best theoretical rationale as a possible ergogenic assist.
Members performed a maximal oxygen consumption exercise take a look at
on an electromagnetically controlled cycle ergometer (Ergometrics
800, Sensormedics, Yorba Linda, CA) to find out their peak oxygen consumption (VO2 peak).
Oxygen uptake in the course of the check was measured through an open-circuit
sampling system (Vmax Encore 29C, Carefusion, Yorba
Linda, CA), and the highest stage of VO2 obtained for 1 min was outlined as VO2 peak.
Respiratory gasoline exchange was measured by having the participant put on a facemask that was connected to
the Encore 29C system. The load on the bike was elevated incrementally so that power output increased 25W per minute.